We investigated the impact of dispersible zinc tablets on postoperative sore throat (POST) experienced by patients after endotracheal intubation. In our study, 88 patients were divided into two groups. One group received a 40 mg zinc tablet, while the other received a placebo 30 minutes before their surgery.
Our findings revealed that the zinc group reported significantly fewer instances of POST at the 4-hour mark compared to the placebo group. Specifically, only 6.8% of patients in the zinc group experienced POST, while a higher 31.8% in the placebo group did. Furthermore, none of the patients taking zinc reported severe sore throat, a stark contrast to three patients in the placebo group who did.
Additionally, we noted lower severity ratings for sore throat in the zinc group at various time intervals post-surgery. The results emphasize that taking zinc tablets before surgery can effectively mitigate the incidence and discomfort of sore throat following intubation, presenting a simple solution for a common postoperative issue.
Read More
9
Zinc reduces postoperative sore throat
The Effect of Zinc Lozenge on Postoperative Sore Throat: A Prospective Randomized, Double-Blinded, Placebo-Controlled Study.
We explored the potential benefits of zinc lozenges for easing postoperative sore throat (POST), a common discomfort following endotracheal intubation. By conducting a randomized, double-blinded trial with 79 patients undergoing low- to moderate-risk surgeries, we divided participants into two groups: one received zinc lozenges, while the other was given a placebo.
Our findings revealed promising results. At the crucial four-hour mark post-surgery, only 7% of patients who took zinc experienced POST, compared to 29% in the placebo group. Interestingly, the difference was even more pronounced right after surgery, where the zinc group reported a 0% incidence of POST versus 24% for the control group.
Moreover, the severity of sore throat symptoms was notably less intense among those in the zinc group. Those with mild and moderate sore throat pains reported significantly lower severity scores. These results suggest that a single dose of 40 mg of zinc lozenges taken just 30 minutes before surgery can greatly aid in reducing both the occurrence and discomfort of POST in the early hours after surgery.
Read More
9.5
Zinc reduces postoperative sore throat
A randomised, double-blind, comparative study of preoperative magnesium sulphate versus zinc sulphate gargle for prevention of postoperative sore throat following endotracheal intubation.
We conducted a study to understand how well zinc can help prevent postoperative sore throat (POST) after endotracheal intubation. We compared the effects of gargling with zinc sulphate versus magnesium sulphate in a controlled trial involving 132 patients. Those in the zinc group received a solution with 40 mg of elemental zinc, while the magnesium group used 20 mg/kg of magnesium sulphate, with a control group receiving only dextrose.
Our findings showed that the group using zinc sulphate experienced notably lower rates of sore throat compared to those using magnesium sulphate. Specifically, the incidence of mild POST was significantly lower in the zinc group, especially during the first four hours after surgery. Overall, zinc gargle proved to be more effective in reducing sore throat compared to magnesium sulphate, demonstrating its potential benefits in postoperative care.
These results highlight the importance of zinc as a simple yet effective intervention to reduce discomfort for patients following surgery. By using zinc gargle preoperatively, we can potentially improve patient outcomes related to postoperative sore throat.
Read More
Most Useful Reviews
9
Reduced throat issues
2 people found this helpful
Great vitamins! I was struggling with hair loss and tried everything. After reading about zinc, I decided to give it a go. After two weeks, I've noticed significant improvements: my hair loss has nearly stopped, my skin is better, and my immunity appears strengthened. I no longer suffer from a sore throat!
Read More
9
Child's health improved
1 people found this helpful
This Zinc Picolinate has become an irreplaceable item, especially with a child at home. I’m on my second jar and am very satisfied. My sore throat issues, which I used to face often, have vanished, even during summer. For any sign of malaise in my child, I administer two tablets for three days, and we avoid health problems.
Read More
9
Lozenge highly recommended
Excellent! I mainly take these lozenges for sore throat. They have a pleasant taste and greatly alleviate discomfort. I highly recommend them!
A randomised, double-blind, comparative study of preoperative magnesium sulphate versus zinc sulphate gargle for prevention of postoperative sore throat following endotracheal intubation.
We conducted a study to understand how well zinc can help prevent postoperative sore throat (POST) after endotracheal intubation. We compared the effects of gargling with zinc sulphate versus magnesium sulphate in a controlled trial involving 132 patients. Those in the zinc group received a solution with 40 mg of elemental zinc, while the magnesium group used 20 mg/kg of magnesium sulphate, with a control group receiving only dextrose.
Our findings showed that the group using zinc sulphate experienced notably lower rates of sore throat compared to those using magnesium sulphate. Specifically, the incidence of mild POST was significantly lower in the zinc group, especially during the first four hours after surgery. Overall, zinc gargle proved to be more effective in reducing sore throat compared to magnesium sulphate, demonstrating its potential benefits in postoperative care.
These results highlight the importance of zinc as a simple yet effective intervention to reduce discomfort for patients following surgery. By using zinc gargle preoperatively, we can potentially improve patient outcomes related to postoperative sore throat.
Read More
9.5
Zinc reduces postoperative sore throat
Preoperative oral zinc tablet decreases incidence of postoperative sore throat.
We investigated the impact of dispersible zinc tablets on postoperative sore throat (POST) experienced by patients after endotracheal intubation. In our study, 88 patients were divided into two groups. One group received a 40 mg zinc tablet, while the other received a placebo 30 minutes before their surgery.
Our findings revealed that the zinc group reported significantly fewer instances of POST at the 4-hour mark compared to the placebo group. Specifically, only 6.8% of patients in the zinc group experienced POST, while a higher 31.8% in the placebo group did. Furthermore, none of the patients taking zinc reported severe sore throat, a stark contrast to three patients in the placebo group who did.
Additionally, we noted lower severity ratings for sore throat in the zinc group at various time intervals post-surgery. The results emphasize that taking zinc tablets before surgery can effectively mitigate the incidence and discomfort of sore throat following intubation, presenting a simple solution for a common postoperative issue.
Read More
9
Zinc reduces postoperative sore throat
The Effect of Zinc Lozenge on Postoperative Sore Throat: A Prospective Randomized, Double-Blinded, Placebo-Controlled Study.
We explored the potential benefits of zinc lozenges for easing postoperative sore throat (POST), a common discomfort following endotracheal intubation. By conducting a randomized, double-blinded trial with 79 patients undergoing low- to moderate-risk surgeries, we divided participants into two groups: one received zinc lozenges, while the other was given a placebo.
Our findings revealed promising results. At the crucial four-hour mark post-surgery, only 7% of patients who took zinc experienced POST, compared to 29% in the placebo group. Interestingly, the difference was even more pronounced right after surgery, where the zinc group reported a 0% incidence of POST versus 24% for the control group.
Moreover, the severity of sore throat symptoms was notably less intense among those in the zinc group. Those with mild and moderate sore throat pains reported significantly lower severity scores. These results suggest that a single dose of 40 mg of zinc lozenges taken just 30 minutes before surgery can greatly aid in reducing both the occurrence and discomfort of POST in the early hours after surgery.
Read More
8
Zinc's role in sore throat treatment
The Effectiveness of a Dietary Supplement with Honey, Propolis, Extract, and Zinc in Children Affected by Acute Tonsillopharyngitis: An Open, Randomized, and Controlled Trial.
We evaluated a promising dietary supplement that combines honey, propolis, and zinc to see how effective it could be for children suffering from acute tonsillopharyngitis, a type of sore throat. In this open-label, randomized, and controlled study, we compared the supplement along with standard care against standard care alone over six days.
The results revealed that incorporating the supplement with standard care led to notable improvements in certain symptoms associated with sore throat, such as throat pain and swallowing difficulties by day four and six. Although zinc was part of the blend, it was challenging to pinpoint its independent effect, given that it was studied alongside honey and propolis.
Interestingly, only one child in the standard care group needed additional medications like ibuprofen, highlighting that the supplement may reduce the need for further treatment. Importantly, we did not report any adverse events, making this combination a potential safe addition to treatment.
Overall, while the study presents encouraging results regarding the adjunctive use of the supplement in treating sore throat, it remains unclear how much zinc alone contributes to its effectiveness.
Read More
8
Zinc's variable effectiveness for sore throat
Zinc deficits, mucositis, and mucosal macrophage perturbation: is there a relationship?
We examined recent findings regarding zinc's impact on sore throat, particularly in post-operative settings. Some studies have reported that specific zinc formulations, like polaprezinc, can effectively reduce symptoms associated with sore throat after procedures like endotracheal intubation.
Importantly, zinc sulfate showed mixed results, with one review suggesting it did not significantly decrease the occurrence or intensity of oral mucositis in cancer patients. However, there are indications that certain zinc preparations may still hold promise in specific contexts, such as managing sore throat post-surgery.
Overall, while zinc's benefits in sore throat treatment appear to vary, ongoing research explores the best applications and formulations of zinc to potentially ease discomfort. As such, individuals seeking relief should keep an eye on emerging studies that could clarify zinc's role in throat health.
Great vitamins! I was struggling with hair loss and tried everything. After reading about zinc, I decided to give it a go. After two weeks, I've noticed significant improvements: my hair loss has nearly stopped, my skin is better, and my immunity appears strengthened. I no longer suffer from a sore throat!
Read More
9
Child's health improved
1 people found this helpful
This Zinc Picolinate has become an irreplaceable item, especially with a child at home. I’m on my second jar and am very satisfied. My sore throat issues, which I used to face often, have vanished, even during summer. For any sign of malaise in my child, I administer two tablets for three days, and we avoid health problems.
Read More
9
Lozenge highly recommended
Excellent! I mainly take these lozenges for sore throat. They have a pleasant taste and greatly alleviate discomfort. I highly recommend them!
Read More
9
Alleviates throat discomfort
I always take these lozenges for sore throat. They have a pleasant taste and are effective; the discomfort greatly lessens.
Read More
9
Softens throat well
I bought it for myself and have not regretted the change to lozenges. They soften my throat well and are effective for sore throat relief.
A sore throat, also known as pharyngitis, is a common condition characterized by pain, scratchiness, or irritation of the throat. It can occur as a result of various factors, including viral infections like the common cold or flu, bacterial infections such as strep throat, allergies, dry air, or even irritants like smoke and pollution. Symptoms often manifest as a sensation of discomfort during swallowing and may be accompanied by swelling, redness, or the presence of white patches on the tonsils or throat lining.
Most sore throats are mild and resolve on their own within a week or so, often treated with home remedies such as warm salt water gargles, lozenges, and hydration. However, if the sore throat is severe, persistent, or associated with other concerning symptoms such as high fever, difficulty swallowing, or difficulty breathing, it's essential to consult a healthcare professional, as this may indicate a more serious condition that requires medical intervention. Proper diagnosis and treatment are crucial, especially if a bacterial infection is suspected, as it may necessitate antibiotics for effective treatment.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc has been studied for its potential effects on the immune system, and some evidence suggests it may help alleviate sore throat symptoms. Particularly, zinc lozenges or syrups may shorten the duration of a sore throat when taken at the onset of symptoms. The reasoning behind this is that zinc can inhibit the replication of the virus responsible for the cold and boost immune response, thus potentially providing some relief.
However, it’s important to use zinc cautiously, as high doses can lead to side effects such as nausea or a bad taste in the mouth. Most health experts recommend opting for zinc in moderate doses, ideally through lozenges, which can also provide some soothing effects. While zinc might not be a cure-all, it can be a helpful part of a broader treatment plan that includes rest, hydration, and over-the-counter pain relievers. If your sore throat persists or is accompanied by other severe symptoms, consulting with a healthcare professional is advisable.
Based on user reviews, the time frame to see results from taking zinc supplements for sore throat can vary. Several users report experiencing relief within a few hours to overnight when taking the supplements at the first sign of symptoms. For instance, one user mentions that after dissolving a zinc pill in their mouth at the onset of sore throat symptoms, they noticed a significant decrease in discomfort by morning (Read Review). Other users have also indicated that maintaining a regimen of zinc, especially when taken alongside vitamin C, has led to a noticeable reduction in sore throat occurrences and improved overall immune support over time (Read Review).
Overall, many users find that taking zinc, particularly in lozenge form, provides quick relief and effective prevention against sore throat, often noting improvements within a matter of hours if started early (Read Review). Additionally, consistent use of the supplement is reported to lead to longer-term benefits, with some users stating they have experienced fewer occurrences of sore throat altogether during cold seasons (Read Review).
Recent research indicates a potential benefit of using a supplement that includes zinc, particularly when combined with other ingredients, for treating sore throat in children. One study focused on a dietary supplement combining honey, propolis, and zinc, which led to improvements in symptoms like throat pain and swallowing difficulties after being incorporated into standard care (see [1]). Another trial specifically assessed a zinc supplement against standard care and found it could alleviate sore throat symptoms, although isolating the impact of zinc alone proved challenging due to the combination of ingredients (see [2]). Overall, the evidence suggests that while zinc may contribute to symptom relief, it often works best when part of a broader treatment strategy.
However, the effectiveness of zinc as a standalone option for sore throat treatment is still under investigation. Some studies have explored zinc in various contexts, such as postoperative sore throat, with mixed results. For instance, investigations on the effects of zinc gargles found that while they might reduce sore throat incidence in postoperative scenarios, the impact wasn't overwhelmingly strong compared to other treatments (see [3] and [4]). In summary, while zinc appears to have a supportive role in managing sore throat symptoms, particularly when combined with other ingredients, further research is needed to clarify its efficacy on its own.
Based on user reviews, many individuals have reported significant improvements in symptoms related to sore throats and overall health after using zinc supplements. For instance, one user highlighted that after just two weeks of zinc use, their hair loss issues subsided, their skin improved, and they noticed no more sore throats (Read Review). Another user expressed satisfaction after their frequent sore throat episodes vanished entirely, even during warmer months, demonstrating the long-term benefits of consistent zinc supplementation for immune health (Read Review).
Additionally, users have frequently mentioned that zinc lozenges provide immediate relief. Many have noted that these lozenges not only taste pleasant but also effectively alleviate discomfort during the early stages of sore throat or cold symptoms. Several reviews mention that relief is felt within a few hours or by the next morning, especially when taken at the first sign of a sore throat (Read Review, Read Review). Overall, while individual results can vary, these anecdotal experiences suggest that zinc can be a valuable supplement for both immediate relief and long-term immune support.
Users report mixed experiences when combining zinc supplements with other supplements, particularly for sore throat management. A notable trend is the pairing of zinc with vitamin C, with one user highlighting that after using both, they experienced a significant decline in illness, enduring only one sickness throughout an entire winter, compared to previous years where tonsillitis was a frequent issue (Read Review). This combination seems to enhance immune support and prevent sore throat symptoms effectively.
Additionally, some users emphasized that taking zinc alone, especially in lozenge form, provides immediate relief at the first sign of a sore throat, while combining it with other remedies, such as vitamin C, may bolster overall effectiveness. For instance, one user mentioned that they include zinc with vitamin C in their regimen specifically to tackle cold symptoms and sore throat when they first emerge (Read Review). Overall, while user experiences may vary, the feedback suggests that combining zinc with other supplements like vitamin C can optimize sore throat relief and boost immune function.
When it comes to treating sore throat, recent research suggests that a dose of 40 mg of zinc may be particularly effective, especially in postoperative settings. For instance, one study involving patients who underwent endotracheal intubation found that those who received zinc tablets before surgery reported significantly fewer instances of postoperative sore throat compared to those who received a placebo. Specifically, only 6.8% of patients in the zinc group experienced sore throat symptoms, contrasting with 31.8% in the placebo group [5].
It's worth noting, however, that while zinc shows promise, the exact impact of zinc itself in more generalized sore throat treatments—like when used alongside other ingredients such as honey and propolis—remains less clear. In studies examining supplements that include zinc, researchers found that while there are significant improvements in symptom alleviation, isolating zinc's specific effects from other components is challenging [1]. Therefore, while a zinc dose of 40 mg appears to help manage sore throat in certain contexts, more research is needed to determine its efficacy as a standalone treatment.
9
Inflammation relief
I always keep this at home. I take zinc if I feel unwell. For oral cavity inflammation, such as colds, sore throat, or stomatitis, I dissolve the pill in my mouth, especially at night, and within a few hours or by morning, symptoms disappear.
7.5
Noticed improvement
I frequently fell ill alongside my daughter whenever she was sick. Tonsillitis was a constant struggle. I gradually started using zinc and vitamin C, and last year I only fell ill once over winter. This year, I've remained healthy since summer! I don’t always follow the dosage strictly but can take three tablets daily if a sore throat arises. The small tablets are easy to consume, and I appreciate the convenience of zinc lozenges that can be transported easily.
9
Child's health improved
1 people found this helpful
This Zinc Picolinate has become an irreplaceable item, especially with a child at home. I’m on my second jar and am very satisfied. My sore throat issues, which I used to face often, have vanished, even during summer. For any sign of malaise in my child, I administer two tablets for three days, and we avoid health problems.
9
Reduced throat issues
2 people found this helpful
Great vitamins! I was struggling with hair loss and tried everything. After reading about zinc, I decided to give it a go. After two weeks, I've noticed significant improvements: my hair loss has nearly stopped, my skin is better, and my immunity appears strengthened. I no longer suffer from a sore throat!
7.5
Home kit essential
A good, necessary thing in the home first aid kit. At the first sign of a cold or sore throat, I take it with vitamin C!
8
Zinc's role in sore throat treatment
The Effectiveness of a Dietary Supplement with Honey, Propolis, Extract, and Zinc in Children Affected by Acute Tonsillopharyngitis: An Open, Randomized, and Controlled Trial.
We evaluated a promising dietary supplement that combines honey, propolis, and zinc to see how effective it could be for children suffering from acute tonsillopharyngitis, a type of sore throat. In this open-label, randomized, and controlled study, we compared the supplement along with standard care against standard care alone over six days.
The results revealed that incorporating the supplement with standard care led to notable improvements in certain symptoms associated with sore throat, such as throat pain and swallowing difficulties by day four and six. Although zinc was part of the blend, it was challenging to pinpoint its independent effect, given that it was studied alongside honey and propolis.
Interestingly, only one child in the standard care group needed additional medications like ibuprofen, highlighting that the supplement may reduce the need for further treatment. Importantly, we did not report any adverse events, making this combination a potential safe addition to treatment.
Overall, while the study presents encouraging results regarding the adjunctive use of the supplement in treating sore throat, it remains unclear how much zinc alone contributes to its effectiveness.
7
Zinc's role in sore throat relief
The Effects of a Dietary Supplement (PediaFlù) Plus Standard of Care in Children With Acute Tonsillopharyngitis/Rhinopharyngitis: Protocol for a Randomized Controlled Trial.
We targeted the effectiveness of a dietary supplement that includes zinc, among other ingredients, in treating acute tonsillopharyngitis and rhinopharyngitis in children. This trial was carefully designed to compare the supplement combined with standard care against standard care alone.
Our focus was on children aged 3 to 10 years suffering from sore throat symptoms. We employed a randomized, controlled setup, ensuring a solid methodological foundation for our findings. The primary goals included assessing severity of throat pain and the necessity for additional rescue medications.
The results highlighted the supplement's potential as an add-on treatment. While it shows promise in alleviating symptoms, we must note that we cannot isolate zinc's effects from other components like Pelargonium sidoides and propolis.
Ultimately, these insights could guide future treatments where antibiotics are avoided, especially when there's no streptococcal infection involved.
4
Zinc's limited impact on POST
Role of preoperative zinc, magnesium and budesonide gargles in Postoperative Sore Throat (POST) - a randomised control trial.
We conducted a thorough investigation into the impact of zinc gargles on postoperative sore throat, commonly known as POST. In our recent randomized control trial, we focused on patients undergoing elective surgeries requiring general anesthesia and found a sizable number experiencing POST.
We compared various treatments, including zinc, magnesium, and budesonide, to see which might lessen the soreness after surgery. Our findings revealed that the effects of zinc were similar to those of the other treatments. Unfortunately, we observed no significant advantage in using zinc to reduce sore throat incidence or severity.
Additionally, we noted that surgeries lasting longer than two hours tended to increase the likelihood of POST, regardless of the treatment used. This indicates that the duration of the surgery is an important factor to consider when evaluating sore throat outcomes, rather than solely the preoperative treatments administered.
9.5
Zinc reduces postoperative sore throat
A randomised, double-blind, comparative study of preoperative magnesium sulphate versus zinc sulphate gargle for prevention of postoperative sore throat following endotracheal intubation.
We conducted a study to understand how well zinc can help prevent postoperative sore throat (POST) after endotracheal intubation. We compared the effects of gargling with zinc sulphate versus magnesium sulphate in a controlled trial involving 132 patients. Those in the zinc group received a solution with 40 mg of elemental zinc, while the magnesium group used 20 mg/kg of magnesium sulphate, with a control group receiving only dextrose.
Our findings showed that the group using zinc sulphate experienced notably lower rates of sore throat compared to those using magnesium sulphate. Specifically, the incidence of mild POST was significantly lower in the zinc group, especially during the first four hours after surgery. Overall, zinc gargle proved to be more effective in reducing sore throat compared to magnesium sulphate, demonstrating its potential benefits in postoperative care.
These results highlight the importance of zinc as a simple yet effective intervention to reduce discomfort for patients following surgery. By using zinc gargle preoperatively, we can potentially improve patient outcomes related to postoperative sore throat.
9.5
Zinc reduces postoperative sore throat
Preoperative oral zinc tablet decreases incidence of postoperative sore throat.
We investigated the impact of dispersible zinc tablets on postoperative sore throat (POST) experienced by patients after endotracheal intubation. In our study, 88 patients were divided into two groups. One group received a 40 mg zinc tablet, while the other received a placebo 30 minutes before their surgery.
Our findings revealed that the zinc group reported significantly fewer instances of POST at the 4-hour mark compared to the placebo group. Specifically, only 6.8% of patients in the zinc group experienced POST, while a higher 31.8% in the placebo group did. Furthermore, none of the patients taking zinc reported severe sore throat, a stark contrast to three patients in the placebo group who did.
Additionally, we noted lower severity ratings for sore throat in the zinc group at various time intervals post-surgery. The results emphasize that taking zinc tablets before surgery can effectively mitigate the incidence and discomfort of sore throat following intubation, presenting a simple solution for a common postoperative issue.
References
Cardinale F, Barattini DF, Martinucci V, Bordea MM, Barattini L, et al. The Effectiveness of a Dietary Supplement with Honey, Propolis, Extract, and Zinc in Children Affected by Acute Tonsillopharyngitis: An Open, Randomized, and Controlled Trial. Pharmaceuticals (Basel). 2024;17. doi:10.3390/ph17060804
Cardinale F, Barattini DF, Sbrocca F, Centi A, Giuntini G, et al. The Effects of a Dietary Supplement (PediaFlù) Plus Standard of Care in Children With Acute Tonsillopharyngitis/Rhinopharyngitis: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2024;13:e53703. doi:10.2196/53703
Bhanwra A, Palta S, Saroa R, Saxena P, Bhanwra S, et al. Role of preoperative zinc, magnesium and budesonide gargles in Postoperative Sore Throat (POST) - a randomised control trial. BMC Anesthesiol. 2024;24:164. doi:10.1186/s12871-024-02534-5
Mondal AK, Maiti AK, Chattopadhyay S, Bhar D. A randomised, double-blind, comparative study of preoperative magnesium sulphate versus zinc sulphate gargle for prevention of postoperative sore throat following endotracheal intubation. Indian J Anaesth. 2023;67:S261. doi:10.4103/ija.ija_975_22
Sarkar T, Mandal T. Preoperative oral zinc tablet decreases incidence of postoperative sore throat. Indian J Anaesth. 2020;64:409. doi:10.4103/ija.IJA_959_19
Thomsen M, Vitetta L. Zinc deficits, mucositis, and mucosal macrophage perturbation: is there a relationship?. Curr Opin Clin Nutr Metab Care. 2019;22:365. doi:10.1097/MCO.0000000000000588
Farhang B, Grondin L. The Effect of Zinc Lozenge on Postoperative Sore Throat: A Prospective Randomized, Double-Blinded, Placebo-Controlled Study. Anesth Analg. 2018;126:78. doi:10.1213/ANE.0000000000002494
Sun GB, Sun N, Tang HH, Zhu QB, Wen W, et al. Zinc sulfate therapy of vocal process granuloma. Eur Arch Otorhinolaryngol. 2012;269:2087. doi:10.1007/s00405-012-1971-1
Prasad AS, Fitzgerald JT, Bao B, Beck FW, Chandrasekar PH. Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2000;133:245.